The synthesis and characterization of [(124)I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease.

Abstract

6-[(124)I]iodo-2-(4'-N,N-dimethylamino)-phenylimidazo[1,2-a]pyridine ([(124)I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [(124)I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.

• Authors: K W Chang, C C Chen, S Y Lee, L H Shen, H E Wang
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) 2009 Jul-Aug Vol. 67 Issue 7-8 Pg. 1397-400 ISSN: 1872-9800 [Electronic] England
• PMID: 19307132 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 6-iodo-2-(4'-dimethylamino-)phenyl-imidazo(1,2-a)pyridine
• Amyloid beta-Peptides
• Benzothiazoles
• Iodine Radioisotopes
• Pyridines
• Thiazoles
• thioflavin T

Topics

• Alzheimer Disease (diagnostic imaging)
• Amyloid beta-Peptides (analysis)
• Animals
• Benzothiazoles
• Brain (diagnostic imaging)
• Disease Models, Animal
• Frontal Lobe (diagnostic imaging)
• Hippocampus (diagnostic imaging)
• Iodine Radioisotopes (pharmacokinetics)
• Mice
• Mice, Transgenic
• Plaque, Amyloid (diagnostic imaging)
• Positron-Emission Tomography
• Pyridines (chemical synthesis, pharmacokinetics)
• Radionuclide Imaging (methods)
• Thiazoles (chemistry)
• Tissue Distribution