Abstract | BACKGROUND: METHODS: A total of 294 Han Chinese men in Taiwan including 132 ASPD with alcoholism (Antisocial ALC) and 162 without alcoholism (Antisocial Non-ALC) were recruited in this study. Alcohol dependence and ASPD were diagnosed according to DSM-IV criteria. Genotypes of ALDH2 and MAOA-uVNTR were determined using PCR-RFLP. RESULTS: A significant difference of ALDH2 polymorphisms (p = 3.39E-05), but not of MAOA, was found among the 2 study groups. However, only after the stratification of the MAOA-uVNTR (variable number of tandem repeat located upstream) 3-repeat, a significant association between Antisocial Non-ALC and ALDH2*1/*2 or *2/*2 genotypes was shown (p = 1.46E-05; odds ratio = 3.913); whereas stratification of MAOA-uVNTR 4-repeat revealed no association. Multiple logistic regression analysis further revealed significant interaction of MAOA and ALDH2 gene in antisocial ALC (odds ratio = 2.927; p = 0.032). CONCLUSION: The possible interaction of MAOA and ALDH2 gene is associated with Antisocial ALC in Han Chinese males in Taiwan. However, the protective effects of the ALDH2*2 allele against alcoholism might disappear in subjects with ASPD and carrying MAOA-uVNTR 4-repeat allele in the Han Chinese male population.
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Authors | Sheng-Yu Lee, Cheng-Yi Hahn, Jia-Fu Lee, Shiou-Lan Chen, Shih-Heng Chen, Tzung Lieh Yeh, Po-Hsiu Kuo, I Hui Lee, Yen Kuang Yang, San-Yuan Huang, Huei-Chen Ko, Ru-Band Lu |
Journal | Alcoholism, clinical and experimental research
(Alcohol Clin Exp Res)
Vol. 33
Issue 6
Pg. 985-90
(Jun 2009)
ISSN: 1530-0277 [Electronic] England |
PMID | 19302089
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ALDH2 protein, human
- Aldehyde Dehydrogenase
- Aldehyde Dehydrogenase, Mitochondrial
- Monoamine Oxidase
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Topics |
- Adult
- Alcoholism
(ethnology, genetics, prevention & control)
- Aldehyde Dehydrogenase
(genetics)
- Aldehyde Dehydrogenase, Mitochondrial
- Alleles
- Antisocial Personality Disorder
(ethnology, genetics)
- Case-Control Studies
- Epistasis, Genetic
(genetics)
- Genotype
- Humans
- Logistic Models
- Male
- Minisatellite Repeats
(genetics)
- Monoamine Oxidase
(genetics)
- Polymorphism, Genetic
(genetics)
- Taiwan
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