Abstract | OBJECTIVE: Adipose tissue has now emerged as a powerful endocrine organ via the production of adipokines. Visfatin, a novel adipokine with diabetogenic and immuno-modulatory properties has been implicated in the pathophysiology of insulin resistance in patients with obesity and Type-2 diabetes mellitus. The aim of this study was to determine whether there are changes in the maternal plasma concentration of visfatin with advancing gestation and as a function of maternal weight. STUDY DESIGN: In this cross-sectional study, maternal plasma concentrations of visfatin were determined in normal weight and overweight/obese pregnant women in the following gestational age groups: 1) 11-14 weeks (n=52); 2) 19-26 weeks (n=68); 3) 27-34 weeks (n=93); and 4) >37 weeks (n=60). Visfatin concentrations were determined by ELISA. Non parametric statistics were used for analysis. RESULTS: 1) The median maternal plasma visfatin concentration was higher in pregnant women between 19-26 weeks of gestation than that of those between 11-14 weeks of gestation (P<0.01) and those between 27-34 weeks of gestation (P<0.01); 2) among normal weight pregnant women, the median plasma visfatin concentrations of women between 19-26 weeks of gestation was higher than that of those between 11-14 weeks (P<0.01) and those between 27-34 weeks (P<0.01); and 3) among overweight/obese patients, the median maternal visfatin concentration was similar between the different gestational age groups. CONCLUSION: The median maternal plasma concentration of visfatin peaks between 19-26 and has a nadir between 27-34 weeks of gestation. Normal and overweight/obese pregnant women differed in the pattern of changes in circulating visfatin concentrations as a function of gestational age.
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Authors | Shali Mazaki-Tovi, Roberto Romero, Juan Pedro Kusanovic, Edi Vaisbuch, Offer Erez, Nandor Gabor Than, Tinnakorn Chaiworapongsa, Chia-Ling Nhan-Chang, Percy Pacora, Francesca Gotsch, Lami Yeo, Sun Kwon Kim, Samuel S Edwin, Sonia S Hassan, Pooja Mittal |
Journal | Journal of perinatal medicine
(J Perinat Med)
Vol. 37
Issue 3
Pg. 206-17
( 2009)
ISSN: 0300-5577 [Print] Germany |
PMID | 19284295
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Chemical References |
- Nicotinamide Phosphoribosyltransferase
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Topics |
- Adult
- Cross-Sectional Studies
- Female
- Gestational Age
- Humans
- Nicotinamide Phosphoribosyltransferase
(blood)
- Obesity
(blood)
- Pregnancy
(blood)
- Pregnancy Complications
(blood)
- Young Adult
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