Abstract |
It has been suggested that the patients with Cushing's disease secondary to pituitary macroadenomas (>10 mm) have higher basal adrenocorticotropic hormone ( ACTH) levels, which are less suppressible on high-dose dexamethasone suppression tests (HDDST). We compared the clinical and biochemical characteristics of patients with macroadenomas (N=7) and microadenomas (N=23) who were diagnosed at Samsung Medical Center in Korea between 1996 and 2006. Basal morning plasma ACTH levels were 101.5+/-23.2 pg/mL for macroadenoma patients and 83.6+/-11.1 pg/mL for microadenoma patients (mean+/-SEMs) (p=0.44). Morning serum cortisol levels were 26.8+/-3.2 microg/dL for macroadenoma patients and 29.5+/-2.9 microg/dL for microadenoma patients (p=0.77). The proportion of patients who showed suppressibility on HDDST was almost identical in the two groups (71.4% [5/7] for macroadenoma patients vs. 72.7% [16/22] for microadenoma patients, p=1.00). Furthermore, the remission rate with trans-sphenoidal surgery was similar between the two groups (100% [5/5] for macroadenoma patients vs. 73.3% [11/15] for microadenoma patients, p=0.53). Thus, tumor size is not a major determinant of hormone secretion or clinical outcomes in patients with Cushing's disease.
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Authors | You-Cheol Hwang, Jae Hoon Chung, Yong-Ki Min, Myung-Shik Lee, Moon-Kyu Lee, Kwang-Won Kim |
Journal | Journal of Korean medical science
(J Korean Med Sci)
Vol. 24
Issue 1
Pg. 46-51
(Feb 2009)
ISSN: 1598-6357 [Electronic] Korea (South) |
PMID | 19270812
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Dexamethasone
- Adrenocorticotropic Hormone
- Hydrocortisone
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Topics |
- Adenoma
(complications, metabolism, surgery)
- Adolescent
- Adrenocorticotropic Hormone
(blood, metabolism)
- Adult
- Aged
- Dexamethasone
(metabolism)
- Female
- Humans
- Hydrocortisone
(blood, metabolism)
- Male
- Middle Aged
- Pituitary ACTH Hypersecretion
(diagnosis, etiology)
- Pituitary Neoplasms
(complications, metabolism, surgery)
- Retrospective Studies
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