Abstract | BACKGROUND: PROCEDURES: We retrospectively reviewed 15 patients who were newly diagnosed to have brainstem tumors and were administered IFN-beta (1-2 MIU/day, days 1-7; 0.5-1 MIU/day, days 8-14) and MCNU (80 mg/m(2) on day 2) concurrently with conventional radiotherapy. Responses were assessed by MRI scan, and data on clinical course and toxicity were obtained from the medical records. The MGMT promoter methylation in serum DNA of five patients was assayed by methylation-specific PCR. RESULTS: Of the 15 patients, partial response, stable disease, and progressive disease were noted in 5 patients each. The median overall survival time and the median progression-free survival time were 14.7 and 4.6 months, respectively. The protocol was not terminated in any of the patients because of hematological toxicity, nephrotoxicity, or neurotoxicity. The MGMT promoter methylation status in the serum appeared to correlate with a positive response to IMR therapy. CONCLUSIONS: The IMR combination therapy is well tolerated and may be a promising treatment for brainstem glioma.
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Authors | Masasuke Ohno, Atsushi Natsume, Masazumi Fujii, Motokazu Ito, Toshihiko Wakabayashi |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 53
Issue 1
Pg. 37-41
(Jul 2009)
ISSN: 1545-5017 [Electronic] United States |
PMID | 19260101
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright 2009 Wiley-Liss, Inc. |
Chemical References |
- Nitrosourea Compounds
- Etoposide
- Interferon-beta
- Dacarbazine
- Carboplatin
- ranimustine
- Temozolomide
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Topics |
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Brain Stem Neoplasms
(diagnosis, drug therapy, mortality, radiotherapy)
- Carboplatin
(administration & dosage)
- Child
- Child, Preschool
- DNA Methylation
(drug effects)
- Dacarbazine
(administration & dosage, analogs & derivatives)
- Disease-Free Survival
- Etoposide
(administration & dosage)
- Female
- Glioma
(diagnosis, drug therapy, mortality, radiotherapy)
- Humans
- Interferon-beta
(administration & dosage)
- Magnetic Resonance Imaging
- Male
- Nitrosourea Compounds
(administration & dosage)
- Retrospective Studies
- Temozolomide
- Treatment Outcome
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