IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation.
Abstract | BACKGROUND: METHODS: The study participants comprised of 102 healthy, overweight and/or obese volunteers (defined as BMI > 25 kg/m2) randomly divided into two groups. The groups received on a daily basis, either 150 mg of IGOB131 or matching placebo in a double blinded fashion, 30-60 minutes before lunch and dinner. At baseline, 4, 8 and 10 weeks of the study, subjects were evaluated for changes in anthropometrics and metabolic parameters to include fasting lipids, blood glucose, C-reactive protein, adiponectin, and leptin. RESULTS: CONCLUSION:
Irvingia gabonensis administered 150 mg twice daily before meals to overweight and/or obese human volunteers favorably impacts body weight and a variety of parameters characteristic of the metabolic syndrome. This is the first double blind randomized placebo controlled clinical trial regarding the anti- obesity and lipid profile modulating effects of an Irvingia gabonensis extract. The positive clinical results, together with our previously published mechanisms of gene expression modulation related to key metabolic pathways in lipid metabolism, provide impetus for much larger clinical studies. Irvingia gabonensis extract may prove to be a useful tool in dealing with the emerging global epidemics of obesity, hyperlipidemia, insulin resistance, and their co-morbid conditions.
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Authors | Judith L Ngondi, Blanche C Etoundi, Christine B Nyangono, Carl Mf Mbofung, Julius E Oben |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 8
Pg. 7
(Mar 02 2009)
ISSN: 1476-511X [Electronic] England |
PMID | 19254366
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Anti-Obesity Agents
- Blood Glucose
- IGOB131
- Leptin
- Placebos
- Plant Extracts
- dikanut
- Cellulose
- Cholesterol
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Topics |
- Adiponectin
(blood)
- Adult
- Africa, Western
- Anti-Obesity Agents
(adverse effects, pharmacology, therapeutic use)
- Blood Glucose
(drug effects)
- Body Weight
(drug effects)
- Cellulose
(chemistry)
- Cholesterol
(blood)
- Double-Blind Method
- Fasting
(blood)
- Feeding Behavior
(drug effects)
- Female
- Humans
- Leptin
(blood)
- Male
- Middle Aged
- Overweight
(blood, drug therapy, metabolism, physiopathology)
- Phytotherapy
- Placebos
- Plant Extracts
(adverse effects, pharmacology, therapeutic use)
- Seeds
(chemistry)
- Waist Circumference
(drug effects)
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