Abstract | BACKGROUND: METHODS: RESULTS: All patients received caffeinol, and most reached target blood levels. Cooling was attempted in 18 patients via endovascular (n = 8) or surface (n = 10) approaches. Two patients were not cooled due to catheter or machine failure. Thirteen patients reached target temperature; average time from symptom onset was 9 hours and 43 minutes. The last 5 hypothermia patients received surface cooling with iced saline induction and larger doses of meperidine; all patients reached target temperature, on average within 2 hours and 30 minutes from induction and 6 hours and 21 minutes from symptom onset. Three patients died: one from symptomatic hemorrhage, one from malignant cerebral edema, and one from unrelated medical complications. No adverse events were attributed to caffeinol. One patient had reduced respiratory drive due to meperidine, requiring BiPAP. DISCUSSION:
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Authors | Sheryl Martin-Schild, Hen Hallevi, Hashem Shaltoni, Andrew D Barreto, Nicole R Gonzales, Jarek Aronowski, Sean I Savitz, James C Grotta |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
2009 Mar-Apr
Vol. 18
Issue 2
Pg. 86-96
ISSN: 1532-8511 [Electronic] United States |
PMID | 19251183
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Adjuvants, Anesthesia
- Anti-Anxiety Agents
- Drug Combinations
- Fibrinolytic Agents
- Neuroprotective Agents
- caffeinol
- Caffeine
- Ethanol
- Meperidine
- Tissue Plasminogen Activator
- Buspirone
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Topics |
- Acute Disease
(therapy)
- Adjuvants, Anesthesia
(administration & dosage)
- Adult
- Aged
- Aged, 80 and over
- Anti-Anxiety Agents
(administration & dosage)
- Brain Ischemia
(physiopathology, therapy)
- Buspirone
(administration & dosage)
- Caffeine
(administration & dosage)
- Drug Combinations
- Ethanol
(administration & dosage)
- Female
- Fibrinolytic Agents
(administration & dosage)
- Humans
- Hypothermia, Induced
(methods)
- Male
- Meperidine
(administration & dosage, adverse effects)
- Middle Aged
- Neuroprotective Agents
(administration & dosage)
- Pilot Projects
- Shivering
(drug effects)
- Stroke
(physiopathology, therapy)
- Thrombolytic Therapy
(methods)
- Tissue Plasminogen Activator
(administration & dosage)
- Treatment Outcome
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