Abstract | OBJECTIVE: Dysfunction of the anterior spinal arteries (ASAs) may induce paresis or paraplegia after thoracoabdominal aortic aneurysm or spine surgery. However, there have been no reports of the effects of CO2 and pH on ASAs. Information on these effects on ASAs might contribute to the perioperative management or critical care of spinal cord function. Thus, we investigated the effects of CO2 and pH on the vasomotor tone of ASAs and the third branch of the middle cerebral artery (bMCA). DESIGN: Prospective study of the effects of CO2 and pH on vasomotor response of porcine ASA and bMCA in vitro. SETTING: University laboratories. SUBJECTS: Porcine heads and spinal cords obtained from a slaughterhouse. INTERVENTION: ASAs and bMCAs were isolated, and changes in the intraluminal region of these pressurized arteries ( approximately 80 mm Hg) were observed for 30 minutes after perfusion with a solution saturated with various concentrations of CO2 and pH. MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS:
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Authors | Seiichiro Kokubun, Satoru Fukuda, Koki Shimoji, Hidetoshi Sakamoto, Sanae Gamou, Mai Ogura, Seki Yunokawa, Shigeho Morita |
Journal | Critical care medicine
(Crit Care Med)
Vol. 37
Issue 3
Pg. 987-92
(Mar 2009)
ISSN: 1530-0293 [Electronic] United States |
PMID | 19237908
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Arteries
(drug effects, metabolism)
- Carbon Dioxide
(pharmacology)
- Hydrogen-Ion Concentration
- In Vitro Techniques
- Middle Cerebral Artery
(drug effects, metabolism)
- Spinal Cord
(blood supply, drug effects)
- Swine
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