Adipokines in the treatment of diabetes mellitus and obesity.

Abstract

BACKGROUND:

The physiology of adipose tissue plays a main role in the pathogenesis of type 2 diabetes mellitus. The secretion of adipocyte-derived hormones, in either an autocrine or a paracrine manner, has been proposed as a relevant mechanism in this process. In this sense, the administration and regulation of hormones derived from adipose tissue arises as an attractive option for treating metabolic disorders.

OBJECTIVE:

To review the current understanding of the implication of adipokines in the development of obesity and insulin resistance, as well as their potential use as therapeutic agents.

METHODOLOGY:

Review of scientific literature.

CONCLUSIONS:

This review describes the role of adipokines in generating insulin resistance and the chronic low-grade inflammatory profile accompanying visceral obesity.

• Authors: Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Javier Salvador, Gema Frühbeck
• Journal: Expert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 10 Issue 2 Pg. 239-54 (Feb 2009) ISSN: 1744-7666 [Electronic] England
• PMID: 19236196 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Adipokines

Topics

• Adipokines (physiology)
• Diabetes Mellitus, Type 2 (complications, drug therapy, physiopathology)
• Humans
• Insulin Resistance
• Intra-Abdominal Fat (physiopathology)
• Obesity (complications, drug therapy, physiopathology)
• Subcutaneous Fat (physiopathology)