Abstract | OBJECTIVE: DESIGN AND PATIENTS: Whole villous tissue and cord serum at birth were collected from 24 AGA and 18 IUGR newborns of comparable gestational age. MEASUREMENTS: Hormonal and peptide concentrations were assayed in placental lysates and cord serum using specific commercial kits. Concentrations in lysates were adjusted per mg of total protein content. RESULTS:
Cortisol, insulin and resistin concentrations and the total amount of insulin receptor were similar in both groups. IL-6 concentration in lysates was significantly higher in IUGR compared with AGA newborns. Adiponectin was significantly lower in lysates from IUGR compared with AGA newborns. Placental insulin and resistin concentrations were positively correlated. Placental adiponectin concentration was positively correlated with the weight of the placenta, birthweight and head circumference. IL-6 concentration in lysates was negatively correlated with birth length, birthweight and head circumference. CONCLUSIONS: This study evaluated the markers of insulin sensitivity in the placentas of subjects born IUGR, showing new potential roles for adiponectin and IL-6 in particular, and suggesting a role for the placenta in the programming of these hormones.
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Authors | Maria E Street, Cecilia Volta, Maria A Ziveri, Isabella Viani, Sergio Bernasconi |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 71
Issue 3
Pg. 394-9
(Sep 2009)
ISSN: 1365-2265 [Electronic] England |
PMID | 19226262
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Insulin
- Interleukin-6
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Topics |
- Adiponectin
(metabolism)
- Birth Weight
- Female
- Fetal Blood
(metabolism)
- Fetal Development
- Fetal Growth Retardation
(blood, metabolism)
- Humans
- Infant, Newborn
- Insulin
(metabolism)
- Interleukin-6
(metabolism)
- Male
- Placenta
(metabolism)
- Pregnancy
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