Abstract | OBJECTIVE: DESIGN: Systematic review and meta-regression analysis of randomised controlled trials. DATA SOURCES: Medline, Embase, Central, CINAHL, and AMED to October 2006 supplemented by contact with experts in the field. STUDY SELECTION: In teams of two, reviewers independently determined eligibility of randomised trials that tested lipid modifying interventions to reduce cardiovascular risk, reported high density lipoprotein cholesterol and mortality or myocardial infarctions separately for treatment groups, and treated and followed participants for at least six months. DATA EXTRACTION AND SYNTHESIS: Using standardised, pre-piloted forms, reviewers independently extracted relevant information from each article. The change in lipid concentrations for each trial and the weighted risk ratios for clinical outcomes were calculated. RESULTS: CONCLUSIONS:
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Authors | Matthias Briel, Ignacio Ferreira-Gonzalez, John J You, Paul J Karanicolas, Elie A Akl, Ping Wu, Boris Blechacz, Dirk Bassler, Xinge Wei, Asheer Sharman, Irene Whitt, Suzana Alves da Silva, Zahira Khalid, Alain J Nordmann, Qi Zhou, Stephen D Walter, Noah Vale, Neera Bhatnagar, Christopher O'Regan, Edward J Mills, Heiner C Bucher, Victor M Montori, Gordon H Guyatt |
Journal | BMJ (Clinical research ed.)
(BMJ)
Vol. 338
Pg. b92
(Feb 16 2009)
ISSN: 1756-1833 [Electronic] England |
PMID | 19221140
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
- Cholesterol, HDL
- Hypolipidemic Agents
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Topics |
- Cardiovascular Diseases
(blood, drug therapy, mortality)
- Cholesterol, HDL
(metabolism)
- Clinical Trials as Topic
- Humans
- Hypolipidemic Agents
(therapeutic use)
- Regression Analysis
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