Abstract |
The case of a 62-year old man diagnosed with radiation-induced meningioma (RIM) after treatment for astrocytoma with an unusually short latency period of 7 months is reported. The patient first presented with a 2-month history of memory decline. Magnetic resonance imaging (MRI) showed a tumour in the left parieto-temporal lobe. Gross total resection was performed and the tumour was confirmed to be an astrocytoma. The patient received cranial radiotherapy 2 weeks later, however 7 months after radiation treatment the patient presented with headache and vomiting. MRI showed massive meningeal enhancement in the left frontal lobe, which progressively enlarged. The patient's clinical condition deteriorated and a second craniotomy was performed with complete removal of the secondary tumour, which was shown to be a malignant meningioma. Immunohistochemical staining identified CD133-positive cells in both tumours. A rare fraction of brain tumour stem cells (BTSC) was isolated from the primary astrocytoma using a serum-free culture system, suggesting that BTSC may have been involved in the rapid emergence of RIM after resection and radiation of the primary astrocytoma.
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Authors | W Hu, F Shen, G Chen, G Shen, W Liu, J Zhou |
Journal | The Journal of international medical research
(J Int Med Res)
2009 Jan-Feb
Vol. 37
Issue 1
Pg. 240-6
ISSN: 0300-0605 [Print] England |
PMID | 19215696
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Astrocytoma
(pathology, radiotherapy, surgery)
- Brain Neoplasms
(pathology, secondary)
- Combined Modality Therapy
- Disease Progression
- Humans
- Magnetic Resonance Imaging
- Male
- Meningioma
(pathology, secondary)
- Middle Aged
- Neoplastic Stem Cells
(pathology)
- Time Factors
- Tumor Cells, Cultured
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