Treatment of nail psoriasis with a two-compound formulation of calcipotriol plus betamethasone dipropionate ointment.

Abstract

BACKGROUND:

Treatment of nail psoriasis remains a challenge.

OBJECTIVE:

To evaluate the efficacy of a two-compound product of calcipotriol plus betamethasone dipropionate ointment on nail psoriasis in an open-label study.

METHODS:

Twenty-five psoriatic patients with nail involvement and mild cutaneous psoriasis were instructed to apply a calcipotriol-betamethasone valerate ointment formulation once daily for 12 weeks on affected nails. Outcome measures were assessed at baseline and at weeks 4, 8 and 12 using the nail psoriasis severity index (NAPSI).

RESULTS:

Twenty-two patients having 114 nails involved at baseline with a mean NAPSI of 5.8 +/- 1.7 were followed up for 12 weeks. The mean NAPSI at the end of the treatment period was reduced to 1.6 +/- 0.6 presenting a 72% improvement. Significant improvement was observed for hyperkeratosis and onycholysis (reduction of mean hyperkeratosis NAPSI from 2.2 +/- 0.5 to 0.5 +/- 0.1 and mean onycholysis NAPSI from 2.0 +/- 0.6 to 0.4 +/- 0.2), moderate improvement for oil drops (reduction of mean oil drop NAPSI from 1.2 +/- 0.4 to 0.8 +/- 0.3) and slight improvement for pitting (reduction of mean pitting NAPSI from 0.8 +/- 0.2 to 0.6 +/- 0.2).

CONCLUSIONS:

The calcipotriol plus betamethasone dipropionate two-compound ointment, applied once daily for 12 weeks, was shown to improve nail psoriasis.

• Authors: D Rigopoulos, S Gregoriou, C R Daniel Iii, H Belyayeva, G Larios, P Verra, C Stamou, G Kontochristopoulos, G Avgerinou, A Katsambas
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 218 Issue 4 Pg. 338-41 ( 2009) ISSN: 1421-9832 [Electronic] Switzerland
• PMID: 19212110 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright 2009 S. Karger AG, Basel.

Chemical References

• Dermatologic Agents
• Drug Combinations
• Ointments
• calcipotriene
• betamethasone-17,21-dipropionate
• Betamethasone
• Calcitriol

Topics

• Betamethasone (administration & dosage, analogs & derivatives)
• Calcitriol (administration & dosage, analogs & derivatives)
• Dermatologic Agents (administration & dosage)
• Drug Combinations
• Humans
• Nail Diseases (drug therapy)
• Ointments
• Psoriasis (drug therapy)