Abstract | BACKGROUND: METHODS: This phase 1, open-label, one-arm study was designed to assess pharmacokinetic interactions and safety of atazanavir, ritonavir, and rifampin among 14 evaluable HIV-seronegative volunteers. The study included 3 sequential periods of study drug dosing, with plasma sampling for pharmacokinetic analyses to occur on the last day of each period. During period 1, participants received rifampin 600 mg every 24 hours for 8 days. During period 2, participants continued rifampin 600 mg every 24 hours, and added atazanavir 300 mg and ritonavir 100 mg every 12 hours, to continue for at least 11 days. During period 3, atazanavir was to be increased to 400 mg every 12 hours. RESULTS: CONCLUSIONS:
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Authors | David W Haas, Susan L Koletar, Laura Laughlin, Michelle A Kendall, Carol Suckow, John G Gerber, Andrew R Zolopa, Richard Bertz, Michael J Child, Lara Hosey, Beverly Alston-Smith, Edward P Acosta, A5213 StudyTeam |
Journal | Journal of acquired immune deficiency syndromes (1999)
(J Acquir Immune Defic Syndr)
Vol. 50
Issue 3
Pg. 290-3
(Mar 01 2009)
ISSN: 1525-4135 [Print] United States |
PMID | 19194314
(Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antitubercular Agents
- HIV Protease Inhibitors
- Oligopeptides
- Pyridines
- Atazanavir Sulfate
- Ritonavir
- Rifampin
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Topics |
- Adult
- Antitubercular Agents
(administration & dosage, adverse effects)
- Atazanavir Sulfate
- Female
- Gastrointestinal Tract
(drug effects)
- HIV Protease Inhibitors
(administration & dosage, adverse effects)
- Humans
- Liver
(drug effects)
- Male
- Oligopeptides
(administration & dosage, adverse effects)
- Pyridines
(administration & dosage, adverse effects)
- Rifampin
(administration & dosage, adverse effects)
- Ritonavir
(administration & dosage, adverse effects)
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