Rosuvastatin 20 mg restores normal HDL-apoA-I kinetics in type 2 diabetes.

Abstract

Catabolism of HDL particles is accelerated in type 2 diabetes, leading to a reduction in plasma residence time, which may be detrimental. Rosuvastatin is the most powerful statin to reduce LDL-cholesterol, but its effects on HDL metabolism in type 2 diabetes remain unknown. We performed a randomized double-blind cross-over trial of 6-week treatment period with placebo or rosuvastatin 20 mg in eight patients with type 2 diabetes. An in vivo kinetic study of HDL-apolipoprotein A-I (apoA-I) with (13)C leucine was performed at the end of each treatment period. Moreover, a similar kinetic study was carried out in eight nondiabetic normolipidemic controls. Rosuvastatin significantly reduced plasma LDL-cholesterol (-51%), triglycerides (TGs) (-38%), and HDL-TG (-23%). HDL-apoA-I fractional catabolic rate (FCR) was decreased by rosuvastatin (0.25 +/- 0.06 vs. 0.32 +/- 0.07 pool/day, P = 0.011), leading to an increase in plasma HDL-apoA-I residence time (4.21 +/- 1.02 vs. 3.30 +/- 0.73 day, P = 0.011). Treatment with rosuvastatin was associated with a concomitant reduction of HDL-apoA-I production rate. The decrease in HDL-apoA-I FCR, induced by rosuvastatin, was correlated with the reduction of plasma TGs and HDL-TG. HDL apoA-I FCR and production rate values in diabetic patients on rosuvastatin were not different from those found in controls. Rosuvastatin is responsible for a 22% reduction of HDL-apoA-I FCR and restores to normal the increased HDL turnover observed in type 2 diabetes. These kinetic modifications may have beneficial effects by increasing HDL plasma residence time.

• Authors: Bruno Vergès, Emmanuel Florentin, Sabine Baillot-Rudoni, Jean-Michel Petit, Marie Claude Brindisi, Jean-Paul Pais de Barros, Laurent Lagrost, Philippe Gambert, Laurence Duvillard
• Journal: Journal of lipid research (J Lipid Res) Vol. 50 Issue 6 Pg. 1209-15 (Jun 2009) ISSN: 0022-2275 [Print] United States
• PMID: 19168444 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoprotein A-I
• Blood Glucose
• Carbon Isotopes
• Cholesterol, HDL
• Cholesterol, LDL
• Fluorobenzenes
• HDL-triglyceride
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Lipoproteins, HDL
• Pyrimidines
• Sulfonamides
• Triglycerides
• Rosuvastatin Calcium

Topics

• Aged
• Apolipoprotein A-I (blood)
• Blood Glucose (metabolism)
• Carbon Isotopes
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Cross-Over Studies
• Diabetes Mellitus, Type 2 (blood, drug therapy)
• Double-Blind Method
• Female
• Fluorobenzenes (administration & dosage, therapeutic use)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage, therapeutic use)
• Kinetics
• Lipoproteins, HDL (blood)
• Male
• Middle Aged
• Pyrimidines (administration & dosage, therapeutic use)
• Rosuvastatin Calcium
• Sulfonamides (administration & dosage, therapeutic use)
• Triglycerides (blood)