Abstract | CONTEXT: OBJECTIVE: We examined the associations between the fractional catabolic rate (FCR) of HDL- apoA-I and VLDL kinetics, plasma adiponectin, and SAA concentrations. STUDY DESIGN: The kinetics of HDL- apoA-I and VLDL- apoB were measured in 50 obese and 37 nonobese men using stable isotopic techniques. RESULTS: In the obese group, HDL- apoA-I FCR was positively correlated with insulin, homeostasis model of assessment for insulin resistance (HOMA-IR) score, triglycerides, VLDL- apoB, and VLDL- apoB production rate (PR). In the nonobese group, HDL- apoA-I FCR was positively correlated with triglycerides, apoC-III, VLDL- apoB, and VLDL- apoB PR and negatively correlated with plasma adiponectin. Plasma SAA was not associated with HDL- apoA-I FCR in either group. In multiple regression analyses, VLDL- apoB PR and HOMA-IR score, and VLDL- apoB PR and adiponectin were independently predictive of HDL- apoA-I FCR in the obese and nonobese groups, respectively. HDL- apoA-I FCR was positively and strongly associated with HDL- apoA-I PR in both groups. CONCLUSIONS: Variation in VLDL- apoB production, and hence plasma triglyceride concentrations, exerts a major effect on the catabolism of HDL- apoA-I. Insulin resistance and adiponectin may also contribute to the variation in HDL- apoA-I catabolism in obese and nonobese subjects, respectively. We also hypothesize that apoA-I PR determines a steady-state, lowered plasma of apoA-I, which may reflect a compensatory response to a primary defect in the catabolism of HDL- apoA-I due to altered VLDL metabolism.
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Authors | Dick C Chan, P Hugh R Barrett, Esther M M Ooi, Juying Ji, Doris T Chan, Gerald F Watts |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 94
Issue 3
Pg. 989-97
(Mar 2009)
ISSN: 1945-7197 [Electronic] United States |
PMID | 19116237
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ADIPOQ protein, human
- Adiponectin
- Apolipoprotein A-I
- Apolipoproteins B
- Lipoproteins, HDL
- Lipoproteins, VLDL
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Topics |
- Adiponectin
(blood)
- Adult
- Apolipoprotein A-I
(metabolism)
- Apolipoproteins B
(metabolism)
- Humans
- Insulin Resistance
- Lipoproteins, HDL
(metabolism)
- Lipoproteins, VLDL
(metabolism)
- Male
- Middle Aged
- Multivariate Analysis
- Obesity
(metabolism)
- Regression Analysis
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