Abstract |
Scrapie is a naturally occurring fatal neurodegenerative disease of sheep and goats. Susceptibility to the disease is partly dependent upon the genetic makeup of the host. In a recent study, it was shown that sheep intracerebrally inoculated with a US scrapie agent (No. 13-7) developed scrapie and survived for an average of 19 months post inoculation. In the present study, when this scrapie inoculum was further passaged for 3 successive generations, the survival time was reduced by approximately 8 months in scrapie-susceptible (QQ on prion protein gene [PRNP] at codon 171) Suffolk sheep. It is concluded that inoculum No. 13-7 appears to have been stabilized in susceptible (171 QQ) Suffolk sheep and may be considered a specific isolate of sheep scrapie agent in the USA and therefore that it can be used to evaluate other isolates of sheep scrapie in this country.
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Authors | A N Hamir, R A Kunkle, J A Richt, J J Greenlee, J M Miller |
Journal | Veterinary pathology
(Vet Pathol)
Vol. 46
Issue 1
Pg. 39-44
(Jan 2009)
ISSN: 0300-9858 [Print] United States |
PMID | 19112113
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Blotting, Western
(veterinary)
- Genetic Predisposition to Disease
(genetics)
- Immunohistochemistry
(veterinary)
- Prions
(genetics)
- Scrapie
(genetics)
- Serial Passage
(veterinary)
- Sheep
- Survival Analysis
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