Abstract | BACKGROUND: METHODS: A randomized, controlled, open-label trial was conducted comparing day 28 PCR corrected cure-rates in 245 children aged 6-59 months, treated over three days with either six-dose of artemether/lumefantrine tablets ( Coartem) or three-dose of artemether/lumefantrine suspension (Co-artesiane) for uncomplicated falciparum malaria in western Kenya. The children were followed-up with clinical, parasitological and haematological evaluations over 28 days. RESULTS: Ninety three percent (124/133) and 90% (121/134) children in the AL tablets and AL suspension arms respectively completed followed up. A per protocol analysis revealed a PCR-corrected parasitological cure rate of 96.0% at Day 28 in the AL tablets group and 93.4% in the AL suspension group, p = 0.40. Both drugs effectively cleared gametocytes and were well tolerated, with no difference in the overall incidence of adverse events. CONCLUSION:
|
Authors | Elizabeth A Juma, Charles O Obonyo, Willis S Akhwale, Bernhards R Ogutu |
Journal | Malaria journal
(Malar J)
Vol. 7
Pg. 262
(Dec 22 2008)
ISSN: 1475-2875 [Electronic] England |
PMID | 19102746
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antimalarials
- Artemether, Lumefantrine Drug Combination
- Artemisinins
- Drug Combinations
- Ethanolamines
- Fluorenes
- Suspensions
- Tablets
|
Topics |
- Analysis of Variance
- Animals
- Antimalarials
(administration & dosage, adverse effects, therapeutic use)
- Artemether, Lumefantrine Drug Combination
- Artemisinins
(administration & dosage, adverse effects, therapeutic use)
- Child, Preschool
- Drug Administration Schedule
- Drug Combinations
- Ethanolamines
(administration & dosage, adverse effects, therapeutic use)
- Fluorenes
(administration & dosage, adverse effects, therapeutic use)
- Follow-Up Studies
- Humans
- Infant
- Kenya
(epidemiology)
- Malaria, Falciparum
(drug therapy, epidemiology, parasitology)
- Plasmodium falciparum
(drug effects, isolation & purification)
- Suspensions
- Tablets
- Treatment Outcome
|