Abstract | BACKGROUND: OBJECTIVE: METHODS: Twelve Sprague-Dawley rats were bled to about 35% of estimated blood volume for 30 min and randomized to one of two groups: the study group received norepinephrine (10 microg/kg/min) in 5% dextrose solution (n = 6); the control group received the same volume of 5% dextrose (n = 6) concurrently with Lactated Ringer's solution. After 30 min of resuscitation, half of the shed blood was transfused in both groups. Time to cardiac arrest and mean arterial pressure (MAP) were compared between the two groups. RESULTS: MAP during the resuscitation period was higher in the norepinephrine group than in the control group. Five of 6 rats in the norepinephrine group but none of the control group survived until the transfusion period (83.3% vs. 0.0%, respectively; p = 0.003). Median time to cardiac arrest was significantly longer in the norepinephrine group (67.0 min, interquartile range [IQR] 60.0-77.0) than in controls (41.0 min, IQR 40.0-47.0; p = 0.002). CONCLUSIONS:
|
Authors | Jae Hyuk Lee, Kyuseok Kim, You Hwan Jo, Kyung Su Kim, Christopher C Lee, Woon Yong Kwon, Joong Eui Rhee, Gil Joon Suh, Adam J Singer |
Journal | The Journal of emergency medicine
(J Emerg Med)
Vol. 37
Issue 4
Pg. 376-82
(Nov 2009)
ISSN: 0736-4679 [Print] United States |
PMID | 19097734
(Publication Type: Journal Article)
|
Chemical References |
- Adrenergic alpha-Agonists
- Norepinephrine
|
Topics |
- Adrenergic alpha-Agonists
(administration & dosage)
- Animals
- Blood Pressure
(drug effects)
- Fluid Therapy
- Heart Arrest
(etiology, prevention & control)
- Infusions, Intravenous
- Kaplan-Meier Estimate
- Male
- Norepinephrine
(administration & dosage)
- Rats
- Rats, Sprague-Dawley
- Shock, Hemorrhagic
(complications, drug therapy, physiopathology)
|