Accruing preclinical evidence about metabotropic glutamate 5 receptor antagonists as treatments for drug dependence highlights the irreplaceable contributions of animal studies to the discovery of new medications for human disorders.

Authors	Athina Markou
Journal	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology) Vol. 34 Issue 4 Pg. 817-9 (Mar 2009) ISSN: 1740-634X [Electronic] England
PMID	19092781 (Publication Type: Comment, Research Support, N.I.H., Extramural)
Chemical References	Excitatory Amino Acid Antagonists Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate
Topics	Animal Experimentation Animals Drug Evaluation, Preclinical Excitatory Amino Acid Antagonists (therapeutic use) Humans Mice Mice, Mutant Strains Rats Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate (antagonists & inhibitors, genetics) Substance-Related Disorders (drug therapy)

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