Abstract | STUDY OBJECTIVES: DESIGN: Cross-sectional study. SUBJECTS AND SETTING: Adult men without prevailing medical comorbidity from the sleep clinic in a teaching hospital. MEASUREMENTS & RESULTS: One hundred thirty-four men underwent polysomnography, with mean age of 43.9 (9.8) years, and median apnea-hypopnea index (AHI) of 17.1 (5.7, 46.6). Overnight urine samples for catecholamines and blood samples for analyses of insulin, glucose and adiponectin levels from fasting subjects were taken. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Magnetic resonance imaging was performed to quantify the amount of abdominal visceral fat. Serum adiponectin level, adjusted for age, body mass index, and visceral fat volume, was significantly lower in subjects with severe obstructive sleep apnea (AHI > or =30) compared with those with an AHI of less than 30: 4.0 (3.1, 5.4) versus 5.4 (3.6, 7.9) microg/mL, P = 0.039. After we adjusted for adiposity, adiponectin levels remained negatively correlated with AHI (P = 0.037), arousal index (P = 0.022), HOMA-IR/fasting insulin (P < 0.001), and urinary norepinephrine and normetanephrine (P < 0.008). In a multiple stepwise regression model, the independent determinants of adiponectin after adjustment for adiposity were HOMA-IR (P < 0.001) and urinary norepinephrine and normetanephrine (P = 0.037). CONCLUSIONS:
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Authors | Jamie C M Lam, Aimin Xu, Sidney Tam, Pek-Ian Khong, Tzy-Jyun Yao, David C L Lam, Agnes Y K Lai, Bing Lam, Karen S L Lam, S M Mary |
Journal | Sleep
(Sleep)
Vol. 31
Issue 12
Pg. 1721-7
(Dec 2008)
ISSN: 0161-8105 [Print] United States |
PMID | 19090328
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adiponectin
(blood)
- Adult
- Body Composition
(physiology)
- Body Mass Index
- Cohort Studies
- Cross-Sectional Studies
- Down-Regulation
(physiology)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Intra-Abdominal Fat
(physiopathology)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Sleep Apnea, Obstructive
(diagnosis, physiopathology)
- Subcutaneous Fat, Abdominal
(physiopathology)
- Sympathetic Nervous System
(physiopathology)
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