Abstract | BACKGROUND:
Lipid levels among contemporary patients hospitalized with coronary artery disease (CAD) have not been well studied. This study aimed to analyze admission lipid levels in a broad contemporary population of patients hospitalized with CAD. METHODS: RESULTS: Of 231,986 hospitalizations from 541 hospitals, admission lipid levels were documented in 136,905 (59.0%). Mean lipid levels were LDL 104.9 +/- 39.8, HDL 39.7 +/- 13.2, and triglyceride 161 +/- 128 mg/dL. Low-density lipoprotein cholesterol <70 mg/dL was observed in 17.6% and ideal levels ( LDL <70 with HDL > or =60 mg/dL) in only 1.4%. High-density lipoprotein cholesterol was <40 mg/dL in 54.6% of patients. Before admission, only 28,944 (21.1%) patients were receiving lipid-lowering medications. Predictors for higher LDL included female gender, no diabetes, history of hyperlipidemia, no prior lipid-lowering medications, and presenting with acute coronary syndrome. Both LDL and HDL levels declined over time (P < .0001). CONCLUSIONS: In a large cohort of patients hospitalized with CAD, almost half have admission LDL levels <100 mg/dL. More than half the patients have admission HDL levels <40 mg/dL, whereas <10% have HDL > or =60 mg/dL. These findings may provide further support for recent guideline revisions with even lower LDL goals and for developing effective treatments to raise HDL.
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Authors | Amit Sachdeva, Christopher P Cannon, Prakash C Deedwania, Kenneth A Labresh, Sidney C Smith Jr, David Dai, Adrian Hernandez, Gregg C Fonarow |
Journal | American heart journal
(Am Heart J)
Vol. 157
Issue 1
Pg. 111-117.e2
(Jan 2009)
ISSN: 1097-6744 [Electronic] United States |
PMID | 19081406
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
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Topics |
- Aged
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Coronary Artery Disease
(blood)
- Female
- Hospitalization
- Humans
- Male
- Triglycerides
(blood)
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