Adenocarcinoma following ileal pouch-anal anastomosis for ulcerative colitis: review of 26 cases.

Abstract

The occurrence of adenocarcinoma following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) is an infrequent and but potentially lethal complication. We have seen 1 such case among 520 IPAAs performed in our group practice between 1978 and February 2008. We have added this case to a review of 25 previously reported cases of adenocarcinoma of the pouch or outflow tract following IPAA for UC. Our conclusions are 1) that post-IPAA cancer can occur following either mucosectomy or stapled anastomosis; 2) that this malignancy can occur after IPAA performed for UC either with or without neoplasia; and 3) that this complication is seen whether or not the initial cancer or dysplasia had involved the rectum.

• Authors: Bernardino C Branco, David B Sachar, Tomas M Heimann, Umut Sarpel, Noam Harpaz, Adrian J Greenstein
• Journal: Inflammatory bowel diseases (Inflamm Bowel Dis) Vol. 15 Issue 2 Pg. 295-9 (Feb 2009) ISSN: 1536-4844 [Electronic] England
• PMID: 19067409 (Publication Type: Case Reports, Journal Article)

Topics

• Adenocarcinoma (complications)
• Adult
• Aged
• Anastomosis, Surgical (adverse effects)
• Colitis, Ulcerative (surgery)
• Colonic Pouches (adverse effects)
• Female
• Humans
• Intestinal Neoplasms (complications)
• Male
• Middle Aged
• Proctocolectomy, Restorative (adverse effects)