Abstract | PURPOSE: To determine whether corneal graft survival over a 5-year follow-up period was affected by ABO blood type compatibility in participants in the Cornea Donor Study undergoing corneal transplantation principally for Fuchs dystrophy or pseudophakic corneal edema, conditions at low-risk for graft rejection. DESIGN: Multi-center prospective, double-masked, clinical trial. METHODS:
ABO blood group compatibility was determined for 1,002 donors and recipients. During a 5-year follow-up period, episodes of graft rejection were documented, and graft failures were classified as to whether or not they were attributable to immunologic rejection. Endothelial cell density was determined by a central reading center for a subset of subjects. RESULTS: ABO donor-recipient incompatibility was not associated with graft failure attributable to any cause including graft failure because of rejection, or with the occurrence of a rejection episode. The 5-year cumulative incidence of graft failure attributable to rejection was 32 (6%) for recipients with ABO recipient-donor compatibility and 12 (4%) for those with ABO incompatibility (hazard ratio, 0.65; 95% confidence interval, 0.33 to 1.25; P = .20). The 5-year incidence for a definite rejection episode, irrespective of whether graft failure ultimately occurred, was 64 (12%) for ABO compatible compared with 25 (8%) for ABO incompatible cases (P = .09). Among clear grafts at 5 years, percent loss of endothelial cells was similar in ABO compatible and incompatible cases. CONCLUSIONS:
|
Authors | Steven P Dunn, Walter J Stark, R Doyle Stulting, Jonathan H Lass, Alan Sugar, Mark A Pavilack, Patricia W Smith, Jean Paul Tanner, Mariya Dontchev, Robin L Gal, Roy W Beck, Craig Kollman, Mark J Mannis, Edward J Holland, Cornea Donor Study Investigator Group |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 147
Issue 3
Pg. 432-438.e3
(Mar 2009)
ISSN: 1879-1891 [Electronic] United States |
PMID | 19056078
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- ABO Blood-Group System
- Rh-Hr Blood-Group System
|
Topics |
- ABO Blood-Group System
(immunology)
- Adult
- Aged
- Aged, 80 and over
- Blood Group Incompatibility
(immunology)
- Cell Count
- Corneal Diseases
(surgery)
- Endothelium, Corneal
- Female
- Graft Rejection
(blood)
- Graft Survival
- Humans
- Keratoplasty, Penetrating
(immunology)
- Male
- Middle Aged
- Prospective Studies
- Rh-Hr Blood-Group System
(immunology)
|