[A-cohort study on the standard short-course chemotherapy program for drug resistant tuberculosis in the rural counties in Eastern China].

Abstract

OBJECTIVE:

To investigate the therapeutic efficacy of short course chemotherapy (SCC) on drug resistant tuberculosis (DR-TB) cases and related influencing socioeconomic factors. TB patients registered in local county TB dispensaries of two rural counties were followed up in Deqing and Guanyun of Eastern China, during 2004/2005.

METHODS:

Culture-positive patients (Deqing: 182, Guanyun: 217) were selected as subjects of this study. A cohort of TB patients was established at the beginning of their treatment and each patient was followed-up three times by questionnaires. Proportional method of drug susceptibility test was used to define the resistance to the 1st-line anti-TB drugs. chi2 test Kaplan-Meier method and Cox analysis were applied in multivariate analysis to investigate the negative conversion of smear positive sputum, treatment result of SCC and its socioeconomic influencing factors.

RESULTS:

The cure rates of multi-drug resistant TB (MDR-TB), other drug resistant TB (ODR-TB) and pan-drug susceptible TB, were 58.3%, 91.0%, 98.7% and 51.3%, 89.5%, 93.5% respectively in Deqing and Guanyun. The liver dysfunction (RR = 0.18, 95% CI: 0.04-0.69) and previous treatment history (RR = 0.26, 95% CI: 0.07-0.93) were associated with treatment result among MDR-TB. Result on treatment in ODR-TB was influenced by previous treatment history (RR = 0.66, 95% CI: 0.44-0.98) and Patient delay (> 2 weeks) (RR = 0.67, 95% CI: 0.46- 0.97).

CONCLUSION:

The priority in treating MDR-TB would include: managing side effect, developing the fast sensitive drug susceptibility test and modifying the treatment regimen corresponding to drug resistance.

• Authors: Yi Hu, Wei-Li Jiang, Wei-Bing Wang, Biao Xu
• Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi (Zhonghua Liu Xing Bing Xue Za Zhi) Vol. 29 Issue 6 Pg. 540-4 (Jun 2008) ISSN: 0254-6450 [Print] China
• PMID: 19040032 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antitubercular Agents
• Rifampin

Topics

• Antitubercular Agents (therapeutic use)
• China (epidemiology)
• Cohort Studies
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Rifampin (therapeutic use)
• Rural Population
• Treatment Outcome
• Tuberculosis, Multidrug-Resistant (drug therapy, epidemiology)
• Tuberculosis, Pulmonary (drug therapy, epidemiology)