Volar melanotic macules are asymptomatic, tan-brown to brownish-black macules found on the palms, fingers, soles, and/or toes of dark-skinned individuals and are infrequently reported in light-skinned individuals. Herein, we report the acquisition of multiple, brownish-black volar digital macules in a 63-year-old white woman and avid gardener that were noted after the onset of pruritic, chronic hand
dermatitis over a 10-month period. She was healthy without any medical conditions or medications. No family history of
intestinal polyposis or mucosal
melanosis existed. At presentation, she had less than 20 brownish-black, 2- to 10-mm irregular macules over the volar aspect of the thumbs and index fingers, left greater than right hand, associated with
erythema, scale, and a negative
potassium hydroxide examination. In addition, she had melanotic macules of her lips, buccal mucosa, and conjuctiva. No nail or anogenital macules were found. Biopsy demonstrated a region of epidermal
hyperplasia, hyperkeratosis, and interface
dermatitis associated with melanophages and sparse lymphocytic infiltrate.
Melanin staining revealed diffuse pan-epidermal hypermelanization, dermal
melanin, and dendritic melanocytes, which expressed HMB-45. After 1-year follow-up and treatment with topical
corticosteroid, the volar macules have faded to tan brown. Based on the location, avocation, and coexisting mucosal melanotic macules, an
irritant phytodermatitis with postinflammatory
hyperpigmentation was diagnosed in the setting of Laugier-Hunziker syndrome-a disorder denoted by macular
hyperpigmentation of nail, volar, and/or mucosal surfaces in healthy adults. Volar melanotic macules can also complicate 5-flourouracil
therapy,
tinea pedis, and other inflammatory disorders; be associated with acral
melanomas; or represent a cutaneous manifestation of systemic disease such as
Addison disease,
Peutz-Jegher syndrome,
Leopard syndrome,
Carney syndrome,
AIDS, and
neurofibromatosis.