Abstract | OBJECTIVE: METHODS: Assessment of the incidence of infection due to Listeria monocytogenes in the Spanish Registry Study (BIOBADASER) per 1000 patient-years and 95% confidence intervals (95% CIs) was performed. Rate from this registry was compared with that from the general population in Europe and with the rate found in patients with rheumatoid arthritis (RA) from the Spanish Rheumatoid Arthritis Registry Cohort Study (EMECAR) that assessed morbidity and clinical expression of RA and included patients treated in most cases with conventional therapies. RESULTS: Six patients on treatment with TNF-alpha antagonists were diagnosed as having Listeria monocytogenes infection. The incidence of this infection per 1000 patient-year (95% CI) was 0.256 (95% CI: 0.115-0.570). This was greater than the incidence observed in the general population from Europe and in the EMECAR study. CONCLUSION: Despite the benefits associated to the use of TNF-alpha antagonists, a high level of surveillance is required to reduce the potential risk of infections related to the use of these drugs.
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Authors | J L Peña-Sagredo, M V Hernández, N Fernandez-Llanio, E Giménez-Ubeda, S Muñoz-Fernandez, A Ortiz, M A Gonzalez-Gay, M C Fariñas, Biobadaser group |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2008 Sep-Oct
Vol. 26
Issue 5
Pg. 854-9
ISSN: 0392-856X [Print] Italy |
PMID | 19032819
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Immunologic Factors
- Recombinant Fusion Proteins
- Tumor Necrosis Factor-alpha
- Infliximab
- Adalimumab
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Topics |
- Adalimumab
- Adult
- Aged
- Antibodies, Monoclonal
(adverse effects)
- Antibodies, Monoclonal, Humanized
- Cohort Studies
- Female
- Humans
- Immunocompromised Host
- Immunologic Factors
(adverse effects, immunology)
- Infliximab
- Listeriosis
(immunology)
- Male
- Middle Aged
- Recombinant Fusion Proteins
(adverse effects, immunology)
- Rheumatic Diseases
(drug therapy, immunology)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
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