Abstract | OBJECTIVE: METHODS: Prospective, double-masked, crossover, active-controlled, randomised 24 h comparison. After a 6 week medicine-free period, patients were randomised to either TTFC or travoprost for 8 weeks and were then switched to the opposite treatment for another 8 weeks. At the end of the washout and treatment periods, a 24 h pressure curve was performed. RESULTS: Thirty-two patients completed the study. The TTFC group demonstrated a lower absolute intraocular pressure level (2.4 mm Hg) for the 24 h curve and at all time points, compared with travoprost (p</=0.047). The pressure reduction from untreated baseline was significantly different between treatments for all time points (p = 0.018). The mean 24 h pressure fluctuation was lower with TTFC (3.0 mm Hg) compared with travoprost (4.0 mm Hg, p = 0.001). No statistical difference existed between the two treatment groups for any adverse event (p>0.05). CONCLUSIONS: This study suggests that when both drugs are dosed in the evening the TTFC provides improved intraocular pressure reduction, compared with travoprost, over the 24 h curve and for each individual time point in primary open-angle glaucoma patients.
|
Authors | A G P Konstas, D Mikropoulos, A-B Haidich, K S Ntampos, W C Stewart |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 93
Issue 4
Pg. 481-5
(Apr 2009)
ISSN: 1468-2079 [Electronic] England |
PMID | 19019932
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antihypertensive Agents
- Drug Combinations
- Cloprostenol
- Timolol
- Travoprost
|
Topics |
- Adult
- Aged
- Antihypertensive Agents
(administration & dosage, adverse effects)
- Circadian Rhythm
- Cloprostenol
(administration & dosage, adverse effects, analogs & derivatives)
- Cross-Over Studies
- Double-Blind Method
- Drug Administration Schedule
- Drug Combinations
- Female
- Glaucoma, Open-Angle
(drug therapy, physiopathology)
- Humans
- Intraocular Pressure
(drug effects)
- Male
- Middle Aged
- Timolol
(administration & dosage, adverse effects)
- Travoprost
- Treatment Outcome
|