Abstract | OBJECTIVE: DESIGN AND METHODS: The study was performed on a Caucasian population of 1045 PC patients and 814 controls. Using a logistic regression model, the different alleles and genotypes from those polymorphisms were analyzed according to case/control status, the tumor aggressiveness, and the age at onset. RESULTS: A significant association between PC risk and the pooled 4/5, 5/6, and 6/6 genotypes of the GGGA repeat located in the first intron of ESR1 (odds ratio (OR)=3.00, 95% CI=1.32-6.82, P=0.008) was observed. When we stratified the cases, this association was confined to patients with a Gleason score of 2-4 (OR=8.34, 95% CI=2.91-23.91, P<0.0001) or late onset PC (OR=2.91, 95% CI=1.22-6.93, P=0.016). An association between a short AR CAG repeat (less than 17 repeats) was also observed among patients with late onset PC (OR=2.34, 95% CI=1.15-4.76, P=0.019). CONCLUSIONS: These findings suggest that the GGGA repeat from ESR1 and the CAG repeat from AR may be associated with risk of late onset PC.
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Authors | Nathalie Nicolaiew, Geraldine Cancel-Tassin, Abdel Rahmene Azzouzi, Beatrice Le Grand, Philippe Mangin, Luc Cormier, Georges Fournier, Jean-Pierre Giordanella, Michel Pouchard, Jean-Louis Escary, Antoine Valeri, Olivier Cussenot |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 160
Issue 1
Pg. 101-6
(Jan 2009)
ISSN: 1479-683X [Electronic] England |
PMID | 18952763
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA, Neoplasm
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Receptors, Androgen
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Topics |
- Adenocarcinoma
(genetics, metabolism)
- Aged
- Aged, 80 and over
- Case-Control Studies
- DNA, Neoplasm
(genetics)
- Estrogen Receptor alpha
(genetics, metabolism)
- Estrogen Receptor beta
(genetics, metabolism)
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Microsatellite Repeats
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prostatic Neoplasms
(genetics, metabolism)
- Receptors, Androgen
(genetics, metabolism)
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