Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking.

Abstract

BACKGROUND:

To report acute and late toxicity in prostate cancer patients treated by dose escalated intensity-modulated radiation therapy (IMRT) and organ tracking.

METHODS:

From 06/2004 to 12/2005 39 men were treated by 80 Gy IMRT along with organ tracking. Median age was 69 years, risk of recurrence was low 18%, intermediate 21% and high in 61% patients. Hormone therapy (HT) was received by 74% of patients. Toxicity was scored according to the CTC scale version 3.0. Median follow-up (FU) was 29 months.

RESULTS:

Acute and maximal late grade 2 gastrointestinal (GI) toxicity was 3% and 8%, late grade 2 GI toxicity dropped to 0% at the end of FU. No acute or late grade 3 GI toxicity was observed. Grade 2 and 3 pre-treatment genitourinary (GU) morbidity (PGUM) was 20% and 5%. Acute and maximal late grade 2 GU toxicity was 56% and 28% and late grade 2 GU toxicity decreased to 15% of patients at the end of FU. Acute and maximal late grade 3 GU toxicity was 8% and 3%, respectively. Decreased late > or = grade 2 GU toxicity free survival was associated with higher age (P = .025), absence of HT (P = .016) and higher PGUM (P < .001).

DISCUSSION:

GI toxicity rates after IMRT and organ tracking are excellent, GU toxicity rates are strongly related to PGUM.

• Authors: Pirus Ghadjar, Jacqueline Vock, Daniel Vetterli, Peter Manser, Roland Bigler, Jan Tille, Axel Madlung, Frank Behrensmeier, Roberto Mini, Daniel M Aebersold
• Journal: Radiation oncology (London, England) (Radiat Oncol) Vol. 3 Pg. 35 (Oct 20 2008) ISSN: 1748-717X [Electronic] England
• PMID: 18937833 (Publication Type: Journal Article)

Topics

• Aged
• Aged, 80 and over
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Proportional Hazards Models
• Prostatic Neoplasms (radiotherapy)
• Radiation Injuries (etiology)
• Radiotherapy Dosage
• Radiotherapy, Intensity-Modulated (adverse effects)
• Recurrence
• Risk
• Time Factors
• Treatment Outcome