Abstract | AIM: MATERIALS AND METHODS: In-phase and opposed-phase gradient-echo MRI images were obtained preoperatively in 37 patients with 38 HCCs before and 15-30 min after intravenous injection of MnDPDP. Subjective ratings of the enhancement degree, the signal-to-noise ratio (SNR) of the lesion and the liver, and the contrast enhancement ratios (CER) were compared with histopathological factors. RESULTS: The mean SNR of HCCs increased from 59.6 to 95.0 (CER=59.5%), whereas that of the liver increased from 75.1 to 108.7 (CER=45.2%). Eight HCCs showed mild enhancement, 11 moderate enhancement, and 15 strong enhancement. There was no visually perceptible enhancement in four HCCs (10.3%). The degree of MnDPDP enhancement was significantly related with the cell density ratio (p<.05) and monoclonal hepatocyte antibody positivity (p<0.005), but not with size, growth type, cell type, histological type, cytokeratin 7, or cytokeratin 19. Well-differentiated HCC showed higher MnDPDP enhancement compared with higher grade HCCs, but the differences were not statistically significant. CONCLUSION: The uptake of MnDPDP by HCC was correlated with hepatocyte antibody expression and the cellular density ratio. Well-differentiated HCC tended to show higher MnDPDP enhancement.
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Authors | J H Kim, M-J Kim, Y N Park, J T Lee, B R Kim, J B Chung, J S Choi, K S Kim, K W Kim |
Journal | Clinical radiology
(Clin Radiol)
Vol. 63
Issue 11
Pg. 1195-204
(Nov 2008)
ISSN: 1365-229X [Electronic] England |
PMID | 18929037
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Pyridoxal Phosphate
- Edetic Acid
- N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
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Topics |
- Adult
- Aged
- Carcinoma, Hepatocellular
(diagnosis, pathology, surgery)
- Cell Differentiation
- Contrast Media
- Edetic Acid
(analogs & derivatives)
- Female
- Humans
- Image Interpretation, Computer-Assisted
(methods)
- Liver Neoplasms
(diagnosis, pathology, surgery)
- Male
- Middle Aged
- Pyridoxal Phosphate
(analogs & derivatives)
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