Abstract | BACKGROUND: We aimed to study serum retinol and alpha-tocopherol in a cohort of obese patients and their possible association with several obesity-related conditions, given that the former may be implicated in a diminished capacity of anti-inflammatory and antioxidant potential in obese patients. METHODS: RESULTS: Both serum retinol and alpha-tocopherol inversely correlated with body mass index (r = -0.334, P = 0.002 and r = -0.299, P = 0.007, respectively). Serum retinol inversely correlated with AST (r = -0.236, P = 0.036) and ALT (r = -0.241, P = 0.032). Multivariate regression analyses confirmed these results after correcting for the effects of other variables. Eighty-five percent of patients had fatty liver. When restricting the analysis to them, multivariate regression identified male sex (beta = 0.451, P = 0.003), age (beta = -0.275, P = 0.039), and serum retinol concentrations (beta = -0.414, P = 0.005) as predictive variables on serum AST (R (2) = 0.230, F = 3.408, P = 0.009) and male sex (beta = 0.448, P = 0.003), age (beta = -0.236, P = 0.046), insulin resistance determined by homeostasis model assessment (beta = 0.243, P = 0.050), and serum retinol concentrations (beta = -0.305, P = 0.022) as predictive variables on serum ALT (R (2) = 0.296, F = 5.817, P = 0.001). CONCLUSION:
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Authors | José I Botella-Carretero, José A Balsa, Clotilde Vázquez, Roberto Peromingo, Manuela Díaz-Enriquez, Héctor F Escobar-Morreale |
Journal | Obesity surgery
(Obes Surg)
Vol. 20
Issue 1
Pg. 69-76
(Jan 2010)
ISSN: 1708-0428 [Electronic] United States |
PMID | 18830789
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vitamin A
- Aspartate Aminotransferases
- Alanine Transaminase
- alpha-Tocopherol
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Topics |
- Adult
- Alanine Transaminase
(blood)
- Aspartate Aminotransferases
(blood)
- Body Mass Index
- Fatty Liver
(blood, diagnostic imaging)
- Female
- Humans
- Linear Models
- Male
- Middle Aged
- Obesity, Morbid
(blood)
- Ultrasonography
- Vitamin A
(blood)
- alpha-Tocopherol
(blood)
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