Comparative study of sucralfate 2 grams twice daily versus sucralfate 1 gram four times daily in the treatment of benign gastric ulcers in outpatients.

Abstract

In a double-blind, randomized study, we compared the healing of gastric ulcer during a twice-daily regimen of 2 g sucralfate or sucralfate 1 g q.i.d. Patients receiving the former therapy received the tablets one-half hour before breakfast and at bedtime. Patients receiving sucralfate 1 g q.i.d. received their therapy 30 minutes before breakfast, lunch, and supper, and at bedtime. The study included 52 patients with endoscopically proven gastric ulcer; 41 patients completed the study. Healing was endoscopically assessed at 8 weeks and 12 weeks. After 8 and 12 weeks the healing rate for sucralfate 2 g b.i.d. was 67% and 92%, respectively; the healing rate of sucralfate 1 g q.i.d. was 59% and 71%, respectively. No statistically significant difference was found between the two regimens. The results suggest that 2 g sucralfate twice daily is as effective in the healing of gastric ulcer as 1 g sucralfate q.i.d.

• Authors: A E Simjee, K E Pettengell, J M Spitaels
• Journal: The American journal of medicine (Am J Med) Vol. 91 Issue 2A Pg. 68S-70S (Aug 08 1991) ISSN: 0002-9343 [Print] United States
• PMID: 1882907 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Sucralfate

Topics

• Adult
• Aged
• Ambulatory Care
• Double-Blind Method
• Endoscopy, Gastrointestinal
• Female
• Humans
• Male
• Middle Aged
• Patient Compliance
• Prospective Studies
• Stomach Ulcer (diagnosis, drug therapy, psychology)
• Sucralfate (administration & dosage, pharmacology, therapeutic use)
• Wound Healing (drug effects)