Development of a contagious ecthyma vaccine for goats.

Abstract

OBJECTIVE:

To identify a strain of contagious ecthyma virus from goats that possesses the appropriate characteristics for an effective vaccine for goats.

ANIMALS:

25 goat kids used for vaccine development and 100 goat kids used for evaluation of vaccine efficacy.

PROCEDURES:

5 strains of contagious ecthyma virus were tested in a vaccination-challenge study to identify the best strain to be the seed strain for a contagious ecthyma vaccine. The vaccine derived from the chosen viral stain was tested at 2 concentrations for efficacy in a vaccination-challenge study.

RESULTS:

2 of 5 viral strains induced moderate to severe scabs following infection, and 3 viral strains protected the goats from wild-type virus challenge following vaccination. Viral strain 47CE was selected as the seed source for the production of a contagious ecthyma vaccine because of the larger vaccine-to-challenge scab formation ratio. Vaccine 47CE protected all goat kids (48/48) following challenge with the wild-type contagious ecthyma virus; all goat kids (32/32) in the control group had scab formation following challenge with the wild-type contagious ecthyma virus, which indicated no protection following administration of vaccine diluent.

CONCLUSIONS AND CLINICAL RELEVANCE:

A vaccine containing a caprine strain of contagious ecthyma virus used in goats appeared to provide the characteristics needed for an effective vaccine, including good scab production and protection from wild-type infection. This vaccine may potentially provide better protection for goats from contagious ecthyma than currently available vaccines labeled for sheep.

• Authors: Jeffrey M B Musser, Charles A Taylor, Jianhua Guo, Ian R Tizard, John W Walker
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 69 Issue 10 Pg. 1366-70 (Oct 2008) ISSN: 0002-9645 [Print] United States
• PMID: 18828697 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Viral Vaccines

Topics

• Animals
• Cicatrix (veterinary, virology)
• Ecthyma, Contagious (immunology)
• Goat Diseases (immunology)
• Goats
• Orf virus (immunology, isolation & purification)
• Vaccination (methods, veterinary)
• Viral Vaccines (adverse effects, therapeutic use)