Successful treatment of adrenocortical carcinoma with pulmonary metastasis in a child: report of a case.

Abstract

Adrenocortical carcinoma (ACC) in childhood is rare: in 2002, only three new cases were reported in Japan. Although there is no established therapeutic management system, margin-free complete surgical excision of the tumor is very important to a satisfactory outcome. We report a case of ACC with bilateral pulmonary metastasis in a 10-year-old boy. Preoperative chest computed tomography (CT) showed pulmonary metastasis with near-water density. The patient was treated successfully with complete surgical resection of the primary tumor and adjuvant chemotherapy, including mitotane. After bilateral lung surgery for the metastatic lesions, the plasma dehydroepiandrosterone sulfate level became negative.

• Authors: Hiromasa Arai, Yasushi Rino, Sumitaka Yamanaka, Norio Yukawa, Nobuyuki Wada, Hiromi Kato, Masakatsu Yanagimachi, Hiroaki Goto, Hisashi Oshiro, Shoji Yamanaka, Yoshiaki Inayama, Jin Lee, Munetaka Masuda
• Journal: Surgery today (Surg Today) Vol. 38 Issue 10 Pg. 965-9 ( 2008) ISSN: 0941-1291 [Print] Japan
• PMID: 18820878 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Mitotane

Topics

• Adrenal Cortex Neoplasms (pathology)
• Adrenocortical Carcinoma (diagnostic imaging, drug therapy, secondary, surgery)
• Antineoplastic Agents, Hormonal (therapeutic use)
• Chemotherapy, Adjuvant
• Child
• Combined Modality Therapy
• Humans
• Lung Neoplasms (diagnostic imaging, drug therapy, secondary, surgery)
• Male
• Mitotane (therapeutic use)
• Tomography, X-Ray Computed