Abstract | BACKGROUND: METHODS: Urine samples from fourteen cases, men diagnosed with Pca, and 125 controls, men who had not been diagnosed with Pca, were partially purified by solid phase extraction and analyzed by ultraperformance liquid chromatography/tandem mass spectrometry. The urinary levels of androgens, estrogens, estrogen metabolites, conjugates and depurinating DNA adducts were measured. RESULTS: The ratio of depurinating estrogen- DNA adducts to the sum of the corresponding estrogen metabolites and conjugates was significantly higher in cases (median: 57.34) compared to controls (median: 23.39) (P < 0.001). CONCLUSIONS: This study suggests that depurinating estrogen- DNA adducts could serve as potential biomarkers to predict risk of Pca. They also could be useful tools for early clinical diagnosis and development of suitable strategies to prevent Pca.
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Authors | Li Yang, Nilesh W Gaikwad, Jane Meza, Ercole L Cavalieri, Paola Muti, Bruce Trock, Eleanor G Rogan |
Journal | The Prostate
(Prostate)
Vol. 69
Issue 1
Pg. 41-8
(Jan 01 2009)
ISSN: 1097-0045 [Electronic] United States |
PMID | 18816637
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright 2008 Wiley-Liss, Inc. |
Chemical References |
- Androgens
- Biomarkers, Tumor
- DNA Adducts
- Estrogens
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Topics |
- Aged
- Aged, 80 and over
- Androgens
(biosynthesis, urine)
- Biomarkers, Tumor
(urine)
- Case-Control Studies
- DNA Adducts
(biosynthesis, urine)
- Early Diagnosis
- Estrogens
(biosynthesis, urine)
- Humans
- Male
- Middle Aged
- Odds Ratio
- Prostatic Neoplasms
(diagnosis, epidemiology, urine)
- Risk Factors
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