Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp. and CRI247-01.

Abstract

Nodulisporacid A (1) was isolated from a marine-derived fungus Nodulisporium sp. CRIF1, while vermelhotin (5) was obtained from an unidentified fungus CRI247-01 (a member of the Order Pleosporales). Both 1 and 5 occurred as equilibrium E/Z mixtures. Ester derivatives (2 and 3) and vermelhotin (5) showed cytotoxic activity against eleven cancer cell lines. Nodulisporacid A (1) and vermelhotin (5) exhibited moderate antiplasmodial activity.

• Authors: Chairut Kasettrathat, Nattaya Ngamrojanavanich, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
• Journal: Phytochemistry (Phytochemistry) Vol. 69 Issue 14 Pg. 2621-6 (Oct 2008) ISSN: 0031-9422 [Print] England
• PMID: 18804825 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimalarials
• Antineoplastic Agents, Phytogenic
• Biological Products
• Furans
• Pyrrolidines
• Pyrrolidinones
• nodulisporacid A
• vermelhotin
• tetramic acid
• tetronic acid
• 4-Butyrolactone

Topics

• 4-Butyrolactone (analogs & derivatives, isolation & purification, pharmacology)
• Animals
• Antimalarials (isolation & purification, pharmacology)
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Biological Products (isolation & purification, pharmacology)
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Furans (isolation & purification, pharmacology)
• Humans
• Molecular Structure
• Plasmodium falciparum (drug effects)
• Pyrrolidines (isolation & purification, pharmacology)
• Pyrrolidinones (isolation & purification, pharmacology)
• Xylariales (chemistry)