Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: RBP4 serum concentration was determined by enzyme-linked immunosorbent assay in 126 nondiabetic and 104 type 2 diabetic subjects. The study population was divided according to estimated glomerular filtration rate (eGFR) into the following groups: eGFR >90 ml/min per 1.73 m(2) (n = 53), 60-90 ml/min per 1.73 m(2) (n = 90), 30-60 ml/min per 1.73 m(2) (n = 38), and <30 ml/min per 1.73 m(2) (n = 49). Each group was subdivided into nondiabetic and type 2 diabetic subjects. RESULTS: RBP4 serum concentration was elevated (2.65 vs. 2.01 micromol/l; P < 0.001) and eGFR was reduced (56 vs. 74 ml/min per 1.73 m(2); P < 0.001) in type 2 diabetic vs. nondiabetic subjects, respectively. By stratifying for eGFR, no more differences in RBP4 serum concentration were detectable between type 2 diabetic and nondiabetic subjects. A linear regression analysis revealed an influence of eGFR (r = -0.477; P < 0.001) but not A1C (r = 0.093; P = 0.185) on RBP4 serum concentration. CONCLUSIONS: Existing human data showing elevated RBP4 levels in type 2 diabetic patients may be the result of moderate renal insufficiency rather than support for the suggestion that RBP4 links obesity to type 2 diabetes.
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Authors | Andrea Henze, Simone K Frey, Jens Raila, Martin Tepel, Alexandra Scholze, Andreas F H Pfeiffer, Martin O Weickert, Joachim Spranger, Florian J Schweigert |
Journal | Diabetes
(Diabetes)
Vol. 57
Issue 12
Pg. 3323-6
(Dec 2008)
ISSN: 1939-327X [Electronic] United States |
PMID | 18796616
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- RBP4 protein, human
- Retinol-Binding Proteins, Plasma
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Topics |
- Biomarkers
(blood)
- Cohort Studies
- Diabetes Mellitus, Type 2
(blood, physiopathology)
- Diabetic Nephropathies
(blood)
- Female
- Glomerular Filtration Rate
- Humans
- Insulin Resistance
(physiology)
- Kidney Function Tests
- Male
- Obesity
(blood)
- Reference Values
- Regression Analysis
- Retinol-Binding Proteins, Plasma
(metabolism)
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