TGF-beta3: A promising growth factor in engineered organogenesis.

Abstract

BACKGROUND:

Engineered organogenesis is one of the most challenging areas on the cutting edge of regenerative medicine. Growth factors can affect cell proliferation, migration and differentiation profoundly, and thus play a critical role in tissue regeneration. TGF-betas produce a wide range of effects in different cells and tissues. TGF-beta3 is relatively recently discovered and studied.

OBJECTIVE:

To provide a broader understanding of the current state of TGF-beta3 in engineered osteogenesis, chondrogenesis, palate development, scar-free wound healing, odontogenesis and neurogenesis.

METHODS:

This review summarizes studies that explore or apply TGF-beta3 for organogenesis with engineering methodology and a regenerative medical perspective.

RESULTS/CONCLUSION:

TGF-beta3 has proven to be a competent growth factor in engineered organogenesis in vitro. In recent years, using TGF-beta3, more and more in vivo studies have yielded significant therapeutic achievements in animal models, which bear much promise for future medical application.

• Authors: Jinghua Hao, Rohan R Varshney, Dong-An Wang
• Journal: Expert opinion on biological therapy (Expert Opin Biol Ther) Vol. 8 Issue 10 Pg. 1485-93 (Oct 2008) ISSN: 1744-7682 [Electronic] England
• PMID: 18774917 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Recombinant Proteins
• Transforming Growth Factor beta3

Topics

• Cell Differentiation (drug effects)
• Cell Movement (drug effects)
• Cell Proliferation (drug effects)
• Humans
• Recombinant Proteins (pharmacology)
• Tissue Engineering
• Tooth (growth & development)
• Transforming Growth Factor beta3 (pharmacology)
• Wound Healing (drug effects)