Abstract | BACKGROUND: METHODS AND RESULTS: One hundred thirty-five consecutive brain dead patients were prospectively screened. Twelve of them with severe acute heart failure defined by an echocardiographic ejection fraction area <30% received 10 microg/kg/min dobutamine infusion over 30 min and, after return to baseline cardiac function, glucose- insulin- potassium infusion over 120 min. With dobutamine, ejection fraction area significantly increased (39 +/- 14 vs. 21 +/- 6%, p < 0.0001) whereas mean diastolic arterial pressure decreased (71 +/- 9 vs. 89 +/- 18 mm Hg, p < 0.05) and heart rate increased (150 +/- 16 vs. 118 +/- 24 beats/min, p < 0.01). After glucose- insulin- potassium infusion, ejection fraction area significantly increased (37 +/- 8 vs. 21 +/- 6%, p < 0.0001), without significant changes in mean arterial blood pressure (79 +/- 16 vs. 89 +/- 18 mm Hg, nonsignificant) and heart rate (116 +/- 18 vs. 118 +/- 24 beats/min, nonsignificant). CONCLUSION:
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Authors | Armelle Nicolas-Robin, Julien Amour, Cristina Ibanez-Esteve, Pierre Coriat, Bruno Riou, Olivier Langeron |
Journal | Critical care medicine
(Crit Care Med)
Vol. 36
Issue 10
Pg. 2740-5
(Oct 2008)
ISSN: 1530-0293 [Electronic] United States |
PMID | 18766095
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Insulin
- glucose-insulin-potassium cardioplegic solution
- Dobutamine
- Glucose
- Potassium
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Topics |
- Adult
- Brain Death
- Confidence Intervals
- Dobutamine
(administration & dosage)
- Drug Therapy, Combination
- Echocardiography, Doppler
- Echocardiography, Transesophageal
- Female
- Follow-Up Studies
- Glucose
(administration & dosage)
- Heart Failure
(diagnostic imaging, drug therapy, prevention & control)
- Heart Rate
(drug effects)
- Heart Transplantation
- Humans
- Infusions, Intravenous
- Insulin
(administration & dosage)
- Male
- Middle Aged
- Organ Preservation
(methods)
- Potassium
(administration & dosage)
- Probability
- Prospective Studies
- Risk Factors
- Severity of Illness Index
- Stroke Volume
(drug effects)
- Tissue Donors
- Treatment Outcome
- Ventricular Remodeling
(drug effects)
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