Adult T-cell leukemia/lymphoma: report of two cases.

Abstract

Adult T-cell leukemia/lymphoma is a lymphoproliferative disorder of mature T lymphocytes associated with infection with human T-cell lymphotrophic virus type I (HTLV-I). Adult T-cell leukemia/lymphoma is characterized by clinical and laboratory polymorphism that allows it to be classified into four distinct subgroups: smoldering, chronic, acute and lymphomatous types. We present here two cases of adult T-cell leukemia/lymphoma, respectively in the acute and lymphomatous forms of the disease. Case 1 was a 35-year-old woman who presented abdominal distension accompanied by hepatosplenomegaly, adenomegaly, skin lesions, positivity for anti-HTLV-I antibodies and leukocytosis with the presence of flower cells. Case 2 was a 38-year-old man who was admitted with generalized lymphadenomegaly, positivity for anti-HTLV-I antibodies, hypercalcemia and osteolytic lesions. In this paper, we correlate the clinical-laboratory findings of these two cases with data in the literature.

• Authors: Ricardo Aparecido Olivo, Fabrício Frederico Mendes Martins, Sheila Soares, Helio Moraes-Souza
• Journal: Revista da Sociedade Brasileira de Medicina Tropical (Rev Soc Bras Med Trop) 2008 May-Jun Vol. 41 Issue 3 Pg. 288-92 ISSN: 0037-8682 [Print] Brazil
• PMID: 18719810 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Fatal Outcome
• Female
• Humans
• Leukemia-Lymphoma, Adult T-Cell (diagnosis, drug therapy)
• Male
• Treatment Outcome