The human G147D-protein phosphatase 1 inhibitor-1 polymorphism is not associated with altered clinical characteristics in heart failure.

Abstract

OBJECTIVES:

A human protein phosphatase inhibitor-1 polymorphism, G147D (c.440G>A, p.147G>D), has been previously demonstrated to blunt the contractile responses of cardiomyocytes to beta-adrenergic agonists. The present study sought to examine whether the G147D inhibitor-1 polymorphism may be associated with specific clinical characteristics of heart failure carriers.

METHODS:

Clinical information of 963 heart failure patients was analyzed according to race, inhibitor-1 genotype, treatment with beta-blockers and mortality patterns.

RESULTS:

The G147D inhibitor-1 genetic variant was found almost exclusively in black subjects and its frequency was similar between normals and heart failure patients, indicating that it was not a primary risk factor for developing heart failure. Comparison of the major cardiac functional parameters and transplant-free survival patterns between carrier and noncarrier patients did not reveal any significant differences. Furthermore, echocardiographic evaluation showed similar outcomes of beta-blocker treatment between G147D carriers and noncarriers.

CONCLUSIONS:

The present findings indicate that the human inhibitor-1 G147D polymorphism, found almost exclusively in blacks, may act as a modifier rather than risk factor in heart failure development.

• Authors: Guoli Chen, Xiaoyang Zhou, Anand Pathak, Gerald W Dorn, Evangelia G Kranias
• Journal: Cardiology (Cardiology) Vol. 112 Issue 3 Pg. 224-31 ( 2009) ISSN: 1421-9751 [Electronic] Switzerland
• PMID: 18698139 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2008 S. Karger AG, Basel.

Chemical References

• Proteins
• PPP1R2C protein, human
• Protein Phosphatase 1

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Black People (genetics, statistics & numerical data)
• Female
• Genetic Predisposition to Disease (ethnology)
• Heart Failure (ethnology, genetics)
• Humans
• Male
• Middle Aged
• Point Mutation
• Polymorphism, Genetic
• Protein Phosphatase 1
• Proteins (genetics)
• Risk Factors
• White People (genetics, statistics & numerical data)
• Young Adult