Abnormal troponin I levels in a thalassemia major patient with high ferritin concentration, permanent atrial fibrillation and without acute coronary syndrome.

Abstract

Thalassemia is a congenital hemoglobinopathy leading to anemia because of impaired erythropoiesis and peripheral hemolysis. Thalassemia major patients are transfusion dependent and it results in iron accumulation. The heart is one of the major organs affected with iron overload and iron induced cardiac dysfunction (pump and conduction abnormalities) remains the number one cause of death among thalassemia major patients. It has been reported that a high ferritin concentration is related to high troponin levels in hemodialysis patients receiving more intravenous iron sucrose. Abnormal troponin I levels have also been reported without acute coronary syndrome. We present a case of abnormal troponin I levels in Thalassemia major patient with high ferritin concentration, permanent atrial fibrillation and without acute coronary syndrome. To our knowledge, this is the first report of abnormal troponin I levels in a Thalassemia major patient with high ferritin concentration and without acute coronary syndrome and also this case focuses attention on the importance of the correct evaluation of abnormal troponin I levels.

• Authors: Salvatore Patanè, Filippo Marte
• Journal: International journal of cardiology (Int J Cardiol) Vol. 138 Issue 2 Pg. e24-7 (Jan 21 2010) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 18687484 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Troponin I
• Ferritins

Topics

• Acute Coronary Syndrome
• Atrial Fibrillation (complications, diagnosis, diagnostic imaging)
• Echocardiography
• Electrocardiography
• Ferritins (blood)
• Humans
• Male
• Middle Aged
• Troponin I (blood)
• beta-Thalassemia (blood, complications)