Subthalamic deep brain stimulation after anesthetic inhalation in Parkinson disease: a preliminary study.

Abstract

OBJECT:

The authors of this preliminary study investigated the outcome and feasibility of intraoperative microelectrode recording (MER) in patients with Parkinson disease (PD) undergoing deep brain stimulation of the subthalamic nucleus (STN) after anesthetic inhalation.

METHODS:

The authors conducted a retrospective analysis of 10 patients with PD who received a desflurane anesthetic during bilateral STN electrode implantation. The MERs were obtained as an intraoperative guide for final electrode implantation and the data were analyzed offline. The functional target coordinates of the electrodes were compared preoperatively with estimated target coordinates.

RESULTS:

Outcomes were evaluated using the Unified Parkinson's Disease Rating Scale 6 months after surgery. The mean improvement in total and motor Unified Parkinson's Disease Rating Scale scores was 54.27 +/- 17.96% and 48.85 +/- 16.97%, respectively. The mean STN neuronal firing rate was 29.7 +/- 14.6 Hz. Typical neuronal firing patterns of the STN and substantia pars nigra reticulata were observed in each patient during surgery. Comparing the functional target coordinates, the z axis coordinates were noted to be significantly different between the pre- and postoperative coordinates.

CONCLUSIONS:

The authors found that MER can be adequately performed while the patient receives a desflurane anesthetic, and the results can serve as a guide for STN electrode implantation. This may be a good alternative surgical method in patients with PD who are unable to tolerate deep brain stimulation surgery with local anesthesia.

• Authors: Sheng-Huang Lin, Tsung-Ying Chen, Shinn-Zong Lin, Ming-Hwang Shyr, Yu-Cheng Chou, Wanhua Annie Hsieh, Sheng-Tzung Tsai, Shin-Yuan Chen
• Journal: Journal of neurosurgery (J Neurosurg) Vol. 109 Issue 2 Pg. 238-44 (Aug 2008) ISSN: 0022-3085 [Print] United States
• PMID: 18671635 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anesthetics, Inhalation
• Anesthetics, Local
• Desflurane
• Isoflurane

Topics

• Aged
• Anesthesia, General (methods)
• Anesthetics, Inhalation (administration & dosage)
• Anesthetics, Local (administration & dosage)
• Deep Brain Stimulation
• Desflurane
• Female
• Humans
• Isoflurane (administration & dosage, analogs & derivatives)
• Male
• Microelectrodes
• Middle Aged
• Parkinson Disease (therapy)
• Pilot Projects
• Retrospective Studies
• Subthalamic Nucleus (physiology)
• Treatment Outcome