Abstract | BACKGROUND: METHODS: RESULTS: For the control and EPA groups combined, a higher number of risk factors was directly associated with an increased incidence of CAD. Incidence was lower for the EPA group than for the control group regardless of the numbers of risk factors. Compared to patients with normal serum TG and HDL-C levels, those with abnormal levels (TG >or=150 mg/dL; HDL-C <40 mg/dL) had significantly higher CAD hazard ratio (HR: 1.71; 95% CI: 1.11-2.64; P=0.014). In this higher risk group, EPA treatment suppressed the risk of CAD by 53% (HR: 0.47; 95% CI: 0.23-0.98; P=0.043). CONCLUSIONS: Multiple risk factors besides cholesterol are associated with markedly increased incidence of CAD. High TG with low HDL-C represents a particularly potent risk factor. EPA was effective in reducing the incidence of CAD events for patients with this dyslipidemic pattern, suggesting that EPA may be especially beneficial in patients who with abnormal TG and HDL-C levels.
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Authors | Yasushi Saito, Mitsuhiro Yokoyama, Hideki Origasa, Masunori Matsuzaki, Yuji Matsuzawa, Yuichi Ishikawa, Shinichi Oikawa, Jun Sasaki, Hitoshi Hishida, Hiroshige Itakura, Toru Kita, Akira Kitabatake, Noriaki Nakaya, Toshiie Sakata, Kazuyuki Shimada, Kunio Shirato, JELIS Investigators, Japan |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 200
Issue 1
Pg. 135-40
(Sep 2008)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 18667204
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Eicosapentaenoic Acid
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Topics |
- Adult
- Aged
- Cholesterol, HDL
(blood)
- Coronary Artery Disease
(prevention & control)
- Dietary Supplements
- Drug Therapy, Combination
- Eicosapentaenoic Acid
(therapeutic use)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Hypercholesterolemia
(complications, drug therapy)
- Hypertriglyceridemia
(complications, drug therapy)
- Japan
- Male
- Metabolic Syndrome
(complications, drug therapy)
- Middle Aged
- Postmenopause
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