An update on the development of drugs against smallpox.

Abstract	The smallpox virus can potentially be used as a biological weapon and pose a serious threat to human populations, thus rendering the development of measures against it particularly important. There is a lack of effective antiviral drugs for the treatment of smallpox and, as a result, a number of viral as well as host targets are being explored in preclinical and clinical studies to assess their efficacy as potential therapeutic agents. This review describes the latest approaches used to develop drugs against smallpox.
Authors	Yuk-Ching Tse-Dinh
Journal	Current opinion in investigational drugs (London, England : 2000) (Curr Opin Investig Drugs) Vol. 9 Issue 8 Pg. 865-70 (Aug 2008) ISSN: 1472-4472 [Print] England
PMID	18666034 (Publication Type: Journal Article, Review)
Chemical References	Antiviral Agents
Topics	Animals Antiviral Agents (pharmacology, therapeutic use) Bioterrorism Drug Delivery Systems Drug Design Drug Therapy, Combination Humans Signal Transduction (drug effects) Smallpox (drug therapy, physiopathology) Variola virus (drug effects, metabolism)

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