This paper studied the use and efficacy of
lamotrigine (LTG), one of the newly developed
antiepileptic medications (
AEM), released via the Special Access Scheme (SAS). It is argued that the SAS application more closely resembles clinical practice and removes the rigours of clinical drug trialing which of themselves may impose confounding variables into the interpretation of
AEM efficacy. Global score evaluation was used to assess efficacy, with scores greater than 4 indicating improvement. Thirty-two patients were administered SAS-LTG, of whom 30 were assessable with a mean
duration of therapy of 90 weeks. Twenty-eight (93.3%) patients were assessed at 6 months; 22 (73.3%) patients were assessed at 12 months. Patients with generalised
epilepsies received lower doses of LTG than those with
partial seizures although this may reflect the use of concomitant
sodium valproate (VPA) which is known to increase LTG half life. LTG produced statistically greater global scores in patients with generalised
epilepsies (mean 5.6 at 6 months) than for those with
partial seizures (mean 4.7 at 6 months). Plasma levels of LTG did not contribute greatly to clinical management. It was concluded that LTG is a relatively safe and effective
AEM for certain patients with
epilepsy who have proven refractory to the older
AEMs. Four patients with refractory generalised
seizures were rendered seizure free with the addition of LTG.