Abstract | OBJECTIVES: METHODS: A total of 36 female rats were divided into six groups: sham operation (control); 3 days, 14 days, and 28 days after BOO; 3 days and 28 days after relief of BOO. Under urethane anesthesia, isovolumetric cystometry was carried out in each group. Then, spinal and serum levels of glutamate and glycine were measured. RESULTS: The interval between bladder contractions was shorter in all of the groups compared with the control group. The amplitude and duration of bladder contractions was decreased at 3 days, 14 days, and 28 days after BOO, and at 3 days after relief of BOO. Spinal and serum glutamate levels showed no changes. However, the spinal glycine level was decreased at 14 days and 28 days after BOO, and at 28 days after relief of BOO. Serum glycine level was also decreased at 28 days after BOO and 28 days after relief of BOO. CONCLUSIONS: Detrusor overactivity during the chronic phase of partial BOO is partly caused by a decrease of glycinergic neuronal activity in the lumbosacral cord. A 3-day period of BOO produces detrusor overactivity, which might be due to an irreversible decrease of spinal glycinergic neuronal activity.
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Authors | Minoru Miyazato, Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Yoshinori Oshiro, Sanehiro Hokama, Atsushi Uchida, Yoshihide Ogawa |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 15
Issue 9
Pg. 843-7
(Sep 2008)
ISSN: 1442-2042 [Electronic] Australia |
PMID | 18637159
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Female
- Glycine
(analysis)
- Lumbar Vertebrae
- Rats
- Rats, Sprague-Dawley
- Sacrum
- Spinal Cord
(chemistry)
- Urinary Bladder
(physiopathology)
- Urinary Bladder Neck Obstruction
(metabolism, physiopathology)
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