Abstract | BACKGROUND: METHODS: On study Day 1, 490 patients received a postoperative initial loading dose of IV parecoxib 40 mg, followed by a re-dose of parecoxib 20 mg in 484 of 490 patients. Subsequently, 479 randomized patients received double-blind treatment with parecoxib 20 mg bid (n = 159), parecoxib 20 mg qd (n = 159) followed by placebo, or placebo (n = 161) on Day 2. RESULTS: Patients treated with parecoxib 20 mg bid reported significantly lower summed pain intensity over 24 h (SPI-24) scores and improved patients' global evaluation of study medication (PGESM) ratings compared with placebo-treated patients on Days 2 to 5 (P < 0.05). For patients treated with parecoxib 20 mg qd, SPI-24 scores were significantly lower on Days 3 and 4 (P < 0.05), and PGESM ratings significantly improved on Day 5 compared with placebo. The incidence of adverse events was similar in all treatment groups with the exception of fever, vomiting and impaired concentration, which were significantly more common in the placebo group compared with one or other of the parecoxib treatment groups (P < 0.05). CONCLUSION:
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Authors | Eugene R Viscusi, Joseph S Gimbel, Andreas M Halder, Michael Snabes, Mark T Brown, Kenneth M Verburg |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 107
Issue 2
Pg. 652-60
(Aug 2008)
ISSN: 1526-7598 [Electronic] United States |
PMID | 18633048
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Cyclooxygenase 2 Inhibitors
- Isoxazoles
- parecoxib
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Analgesics
(administration & dosage, adverse effects)
- Arthroplasty, Replacement, Hip
- Cyclooxygenase 2 Inhibitors
(administration & dosage, adverse effects)
- Double-Blind Method
- Drug Administration Schedule
- Female
- Humans
- Isoxazoles
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Patient Satisfaction
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