Kounis syndrome secondary to amoxicillin/clavulanic acid use in a child.

Abstract

The concurrence of acute coronary syndromes with allergic or hypersensitivity as well as with anaphylactic or anaphylactoid reactions is increasingly encountered in clinical practice and there are several reports associating mast cell activation with acute cardiovascular events in adults. It was first described by Kounis as "allergic angina syndrome" progressing to "allergic myocardial infarction". The main mechanism proposed is the vasospasm of coronary arteries. This condition has not been described in childhood. We present a 13-year-old boy, admitted to our hospital with thoracic pain, 30 min after the ingestion of an oral dose of 500 mg of amoxicillin/clavulanic acid.

• Authors: Murat Biteker, Nilüfer Ekşi Duran, Funda Sungur Biteker, Emre Ertürk, Ahmet Cağri Aykan, Hasret Ayyildiz Civan, Mehmet Ozkan
• Journal: International journal of cardiology (Int J Cardiol) Vol. 136 Issue 1 Pg. e3-5 (Jul 24 2009) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 18632172 (Publication Type: Case Reports, Letter)

Chemical References

• Clavulanic Acid
• Amoxicillin

Topics

• Acute Coronary Syndrome (chemically induced, diagnosis, physiopathology)
• Adolescent
• Amoxicillin (administration & dosage, adverse effects)
• Clavulanic Acid (administration & dosage, adverse effects)
• Drug Hypersensitivity (diagnosis, etiology, physiopathology)
• Echocardiography
• Humans
• Male
• Myocardial Infarction (chemically induced, diagnosis, physiopathology)